In the end I think this will be down to personal preference.
If you have two different topic areas that you talk about and want to keep separate, like philosophy and sports, then I can see the value in more than one account.
Otherwise I would consider using lists to get different feeds for different groups of people.
I've tried multiple accounts in the past and never really found a good way of managing it.
I prefer a personal instance as I then control federation myself... :)