Just made a clickable prototype in PDF. If I make buttons and links clickable in a Keynote document (so they jump to the correct page), those links are carried over when I export to PDF. Been doing this for many years now.
The client was blown away. They can use that file for demos and testing. And it's one portable file. Sometimes simplicity is key. You wouldn't believe how much money and time I've saved not using Adobe products.
And no, it's not right for every use case.